Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcription activating and repressing functions of the androgen receptor are differentially influenced by mutations in the deoxyribonucleic acid-binding domain.

Endocrinology - 1 Jul 1999

Aarnisalo P, Santti H, Poukka H, Palvimo J J, Jänne O A

Abstract excerpt

Despite the wide spectrum of androgen receptor (AR) mutants described in androgen insensitivity syndromes (AIS), their influence on transactivating and, in particular, transrepressing functions of AR are poorly defined. Rat AR mutants with substitutions in the DNA-binding domain, corresponding to several mutations in AIS patients, were examined for these activities. AR variants (G551V and C562G) with mutations in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COS Cells
Share to CREB-Binding Protein

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to NF-kappa B

Share to Nuclear Proteins

Share to Receptors, Androgen

Share to Trans-Activators

Share to Transcription Factor AP-1

Share to Transcriptional Activation

Source

Identifiers

PMID: 10385402
DOI: 10.1210/endo.140.7.6792

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcription activating and repressing functions of the androgen receptor are differentially influenced by mutations in the deoxyribonucleic acid-binding domain.PMID 10385402Read ↗

Androgen insensitivity syndrome due to new mutations in the DNA-binding domain of the androgen receptor.Semantic proximity Read ↗

Disrupted Amino- and Carboxyl-Terminal Interactions of the Androgen Receptor Are Linked to Androgen InsensitivitySemantic proximity Read ↗

Five novel androgen receptor gene mutations associated with complete androgen insensitivity syndrome.Semantic proximity Read ↗

Identification of a highly conserved domain in the androgen receptor that suppresses the DNA-binding domain-DNA interactions.Semantic proximity Read ↗

Delineation of two distinct type 1 activation functions in the androgen receptor amino-terminal domain.Semantic proximity Read ↗

Variable loss of functional activities of androgen receptor mutants in patients with androgen insensitivity syndrome.Semantic proximity Read ↗

Diverse roles of androgen receptor (AR) domains in AR-mediated signalingSemantic proximity Read ↗

Transcriptional interferences between normal or mutant androgen receptors and the activator protein 1--dissection of the androgen receptor functional domains.Semantic proximity Read ↗

Human androgen insensitivity syndrome.Semantic proximity Read ↗

Genetic Findings in a Cohort of Patients with Androgen Insensitivity SyndromeSemantic proximity Read ↗

[Identification of a highly conserved domain that suppresses the DNA-binding domain-DNA interactions in the androgen receptor].Semantic proximity Read ↗

Human gene mutations. Gene symbol: AR. Disease: Androgen insensitivity syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.