Article
Integrity of p53 in hepatitis B x antigen-positive and -negative hepatocellular carcinomas.
Cancer research - 1 Feb 1997
Greenblatt M S, Feitelson M A, Zhu M, Bennett W P, Welsh J A, Jones R, Borkowski A, Harris C C
Abstract excerpt
Inactivation of the tumor suppressor p53 seems to be important to the pathogenesis of hepatocellular carcinoma (HCC) associated with chronic hepatitis B virus infection. Although this inactivation may be due to mutations in the p53 gene, recent evidence suggests that the hepatitis B virus-encoded X antigen (HBxAg) binds to and inactivates wild-type p53. Hence, experiments were designed to test the hypothesis that...
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