Article
Identification of a gene that causes primary open angle glaucoma.
Science (New York, N.Y.) - 31 Jan 1997
Stone E M, Fingert J H, Alward W L, Nguyen T D, Polansky J R, Sunden S L, Nishimura D, Clark A F, Nystuen A, Nichols B E, Mackey D A, Ritch R, Kalenak J W, Craven E R, Sheffield V C
Abstract excerpt
Glaucoma is a major cause of blindness and is characterized by progressive degeneration of the optic nerve and is usually associated with elevated intraocular pressure. Analyses of sequence tagged site (STS) content and haplotype sharing between families affected with chromosome 1q-linked open angle glaucoma (GLC1A) were used to prioritize candidate genes for mutation screening. A gene encoding a trabecular...
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