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Article

Increased survival of CFTR knockout mice with an oral osmotic laxative.

Laboratory animal science - 1 Dec 1996

Clarke L L, Gawenis L R, Franklin C L, Harline M C

Abstract excerpt

Mouse models of cystic fibrosis that are generated by targeted disruption (knockout) of the cystic fibrosis transmembrane conductance regulator gene, cftr(-/-), typically die shortly after weaning, from intestinal obstruction/rupture caused by an inability to secrete fluid into the bowel lumen. We investigated the use of a commercial osmotic laxative, Colyte, provided continuously in the drinking water, to...

Read the complete abstract on PubMed

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Share to Cystic Fibrosis
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Mice, Inbred BALB C

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Source

Identifiers

PMID: 9001172

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Increased survival of CFTR knockout mice with an oral osmotic laxative.PMID 9001172Read ↗

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Active intestinal chloride secretion in human carriers of cystic fibrosis mutations: an evaluation of the hypothesis that heterozygotes have subnormal active intestinal chloride secretion.Semantic proximity Read ↗

Consuming Genistein Improves Survival Rates in the Absence of Laxative in Δf508-Cf Female MiceSemantic proximity Read ↗

Additional disruption of the ClC-2 Cl(-) channel does not exacerbate the cystic fibrosis phenotype of cystic fibrosis transmembrane conductance regulator mouse models.Semantic proximity Read ↗

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