Article
Cse1l is a negative regulator of CFTR-dependent fluid secretion.
Current biology : CB - 26 Oct 2010
Bagnat Michel, Navis Adam, Herbstreith Sara, Brand-Arzamendi Koroboshka, Curado Silvia, Gabriel Sherif, Mostov Keith, Huisken Jan, Stainier Didier Y R
Abstract excerpt
Transport of chloride through the cystic fibrosis transmembrane conductance regulator (CFTR) channel is a key step in regulating fluid secretion in vertebrates [1, 2]. Loss of CFTR function leads to cystic fibrosis [1, 3, 4], a disease that affects the lungs, pancreas, liver, intestine, and vas deferens. Conversely, uncontrolled activation of the channel leads to increased fluid secretion and plays a major role...
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