Article
Expression of wild-type p53 stimulates an increase in both Bax and Bcl-xL protein content in HT29 cells.
Oncogene - 19 Dec 1996
Merchant A K, Loney T L, Maybaum J
Abstract excerpt
It has been shown previously that wild-type p53 activity can simultaneously up-regulate Bax, a protein which predisposes cells to programmed cell death (PCD), and down-regulate Bcl-2, a protein which antagonizes PCD. These findings have been interpreted to suggest that correction of the mutant p53 status of some tumor cells may be a means of increasing their sensitivity to chemotherapeutic agents, by increasing...
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