Article
Synthesis and siderophore and antibacterial activity of N5-acetyl-N5-hydroxy-L-ornithine-derived siderophore-beta-lactam conjugates: iron-transport-mediated drug delivery.
Journal of medicinal chemistry - 1 Mar 1991
Dolence E K, Minnick A A, Lin C E, Miller M J, Payne S M
Abstract excerpt
N5-Acetyl-N5-hydroxy-L-ornithyl-N5-acetyl-N5-hydroxy-L-ornithyl-N5-acety l- N5-hydroxy-L-ornithine, the functionally instrumental component of the albomycins and ferrichromes, has been incorporated as a "carrier" substructure into both carbacephalosporin and oxamazin type beta-lactam antibiotics....
Topics
- Anti-Bacterial Agents
- Azetidines
- Biological Transport
- Cephalosporins
- Chemical Phenomena
- Chemistry
- Drug Carriers
- Escherichia coli
- Ferrichrome
- Iron
- Iron Chelating Agents
- Lactams
- Molecular Structure
- Mutation
- Shigella flexneri
- Siderophores
- beta-Lactams