Article
Self-poisoning of Mycobacterium tuberculosis by interrupting siderophore recycling.
Proceedings of the National Academy of Sciences of the United States of America - 4 Feb 2014
Jones Christopher M, Wells Ryan M, Madduri Ashoka V R, Renfrow Matthew B, Ratledge Colin, Moody D Branch, Niederweis Michael
Abstract excerpt
Siderophores are small iron-binding molecules secreted by bacteria to scavenge iron. Mycobacterium tuberculosis (Mtb), the etiologic agent of tuberculosis, produces the siderophores mycobactin and carboxymycobactin. Complexes of the mycobacterial membrane proteins MmpS4 and MmpS5 with the transporters MmpL4 and MmpL5 are required for siderophore export and virulence in Mtb. Here we show that, surprisingly,...
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