Article
Species selectivity of new siderophore-drug conjugates that use specific iron uptake for entry into bacteria.
Antimicrobial agents and chemotherapy - 1 Nov 1996
Diarra M S, Lavoie M C, Jacques M, Darwish I, Dolence E K, Dolence J A, Ghosh A, Ghosh M, Miller M J, Malouin F
Abstract excerpt
Siderophores selectively bind ferric iron and are involved in receptor-specific iron transport into bacteria. Several types of siderophores were synthesized, and growth-promoting or inhibitory activities when they were conjugated to carbacephalosporin, erythromycylamine, or nalidixic acid were in...
Topics
- Animals
- Anti-Bacterial Agents
- Bacteria
- Bacterial Outer Membrane Proteins
- Bordetella
- Colicins
- Drug Resistance, Microbial
- Escherichia coli
- Hydroxamic Acids
- Iron
- Microbial Sensitivity Tests