Article
The teratogenic action of retinoic acid in rat congenic and recombinant inbred strains.
Folia biologica - 1 Jan 1996
Bílá V, Kren V
Abstract excerpt
The teratogenic effect of all-trans retinoic acid (RA) was tested in the system of congenic and recombinant inbred (RI) strains of the laboratory rat carrying the mutant Lx allele which determines the polydactyly-luxate syndrome. It was demonstrated that the teratogenic effect of RA is influenced by both the genotype at the Lx locus and the modifying genes. The dose of 100 mg/kg administered by gavage on day 11...
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