Evidence for teratogenicity of thalidomide using congenic and recombinant inbred rat strains.

Article

Evidence for teratogenicity of thalidomide using congenic and recombinant inbred rat strains.

Folia biologica - 1 Jan 1994

Bílá V, Kren V

Abstract excerpt

Teratogenic properties of thalidomide were tested in two systems of laboratory rat strains carrying the mutant lx allele that determines the polydactyly-luxate syndrome. In agreement with our previous experiments, we have confirmed that the response of foetuses basically depends on their genotype...

Topics

Abnormalities, Drug-Induced
Alleles
Animals
Embryonic and Fetal Development
Female
Fetus
Genotype
Injections, Intraperitoneal
Limb Deformities, Congenital
Male
Pregnancy
Rats
Rats, Inbred BN
Rats, Inbred Lew
Rats, Inbred SHR
Thalidomide

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