Article
The influence of the genetic background on the interaction of retinoic acid with Lx mutation of the rat.
Folia biologica - 1 Jan 2000
Bíla V, Kren V, Liska F
Abstract excerpt
The teratogenic effect of RA was found to be significantly influenced both by genetic background and by the genotype of malformation mutation Lx. The presence of the Lx mutation and BN genetic background strongly increases the teratogenic effect of RA. On the contrary, the SHR genetic background was shown to protect foetuses from RA teratogenic affliction. Recombinant inbred strain BXH2 is endowed with a specific...
Topics
- Abnormalities, Drug-Induced
- Abnormalities, Multiple
- Alleles
- Animals
- Animals, Congenic
- Crosses, Genetic
- Embryonic and Fetal Development
- Face
- Female
- Forelimb
- Genetic Predisposition to Disease
- Genotype
- Gestational Age
- Hindlimb
- Male
- Morphogenesis
- Polydactyly
- Rats