Article
Teratogenicity testing based on the interaction with a mutant allele.
Folia biologica - 1 Jan 1992
Bílá V, Kren V
Abstract excerpt
The system of congenic strains of the laboratory rat carrying the mutant allele lx which is determining the polydactyly-luxate syndrome (PLS) was used for testing teratogenicity of six compounds from different pharmacological groups (cyclophosphamide, cyadox, carbadox, imipramine, verapamil, TIA). The interaction of the mutant lx allele with cyclophosphamide was highly significant (P less than 0.001) involving...
Topics
- Abnormalities, Drug-Induced
- Alleles
- Animals
- Anti-Bacterial Agents
- Cyclophosphamide
- Female
- Fetus
- Imipramine
- Male
- Mutagenicity Tests
- Rats
- Rats, Inbred Lew