Article
A rat mutation producing demyelination (dmy) maps to chromosome 17.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Dec 1996
Kuramoto T, Sotelo C, Yokoi N, Serikawa T, Goñalons Sintes E, Cantó Martorell J, Guénet J L
Abstract excerpt
A recessive mutation exhibiting severe myelin breakdown, mainly at the level of the lumbar segments of the spinal cord and without any associated inflammation, was discovered in a partially inbred rat colony. Analysis of the segregation patterns of a set of polymorphic microsatellite markers in two inter-strain crosses allowed the mapping of this autosomal recessive mutation to rat Chromosome (Chr) 17, very close...
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