Article
pain2: A neuropathic pain QTL identified on rat chromosome 2.
Pain - 1 Mar 2008
Nissenbaum Jonathan, Shpigler Hagai, Pisanté Anne, DelCanho Sonia, Minert Anne, Seltzer Ze'ev, Devor Marshall, Darvasi Ariel
Abstract excerpt
We aimed to locate a chronic pain-associated QTL in the rat (Rattus norvegicus) based on previous findings of a QTL (pain1) on chromosome 15 of the mouse (Mus musculus). The work was based on rat selection lines HA (high autotomy) and LA (low autotomy) which show a contrasting pain phenotype in response to nerve injury in the neuroma model of neuropathic pain. An F(2) segregating population was generated from HA...
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