Article
Pathogenic potential of environmental Vibrio cholerae strains carrying genetic variants of the toxin-coregulated pilus pathogenicity island.
Infection and immunity - 1 Feb 2003
Faruque Shah M, Kamruzzaman M, Meraj Ismail M, Chowdhury Nityananda, Nair G Balakrish, Sack R Bradley, Colwell Rita R, Sack David A
Abstract excerpt
The major virulence factors of toxigenic Vibrio cholerae are cholera toxin (CT), which is encoded by a lysogenic bacteriophage (CTXPhi), and toxin-coregulated pilus (TCP), an essential colonization factor which is also the receptor for CTXPhi. The genes for the biosynthesis of TCP are part of a larger genetic element known as the TCP pathogenicity island. To assess their pathogenic potential, we analyzed...
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