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Article

The role of toxin-coregulated pili in the pathogenesis of Vibrio cholerae O1 El Tor.

Microbial pathogenesis - 1 Dec 1993

Attridge S R, Voss E, Manning P A

Abstract excerpt

Studies in the infant mouse cholera model have evaluated the significance of toxin-coregulated pili (TCP) in the pathogenesis of Vibrio cholerae strains of El Tor biotype. Four El Tor strains--two which produce TCP during in vitro growth and two which do not--were mutated by the insertion of an a...

Topics

Animals
Bacterial Proteins
Bacterial Toxins
Base Sequence
Blotting, Southern
Cholera
Cloning, Molecular
DNA, Bacterial
Fimbriae Proteins
Fimbriae, Bacterial
Immunoblotting
Mice
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Vibrio cholerae

Virulence

Source

Identifiers

PMID: 7911968
DOI: 10.1006/mpat.1993.1091

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7911968-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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The role of toxin-coregulated pili in the pathogenesis of Vibrio cholerae O1 El Tor.PMID 7911968Read ↗

Pathogenic and vaccine significance of toxin-coregulated pili of Vibrio cholerae E1 Tor.Semantic proximity Read ↗

Relative significance of mannose-sensitive hemagglutinin and toxin-coregulated pili in colonization of infant mice by Vibrio cholerae El Tor.Semantic proximity Read ↗

TcpF is a soluble colonization factor and protective antigen secreted by El Tor and classical O1 and O139 Vibrio cholerae serogroups.Semantic proximity Read ↗

Pathogenic potential of environmental Vibrio cholerae strains carrying genetic variants of the toxin-coregulated pilus pathogenicity island.Semantic proximity Read ↗

Evolutionary and functional analyses of variants of the toxin-coregulated pilus protein TcpA from toxigenic Vibrio cholerae non-O1/non-O139 serogroup isolates.Semantic proximity Read ↗

Cyclic AMP and its receptor protein negatively regulate the coordinate expression of cholera toxin and toxin-coregulated pilus in Vibrio cholerae.Semantic proximity Read ↗

Use of signature-tagged transposon mutagenesis to identify Vibrio cholerae genes critical for colonization.Semantic proximity Read ↗

Single amino acid substitutions in the N-terminus of Vibrio cholerae TcpA affect colonization, autoagglutination, and serum resistance.Semantic proximity Read ↗

Epitope differences in toxin-coregulated pili produced by classical and El Tor Vibrio cholerae O1.Semantic proximity Read ↗

Delineation of pilin domains required for bacterial association into microcolonies and intestinal colonization by Vibrio cholerae.Semantic proximity Read ↗

Crystal structure of the Vibrio cholerae colonization factor TcpF and identification of a functional immunogenic site.Semantic proximity Read ↗

Inactivated Vibrio cholerae Strains That Express TcpA via the toxT-139F Allele Induce Antibody Responses against TcpA.Semantic proximity Read ↗

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