A modification of the local lymph node assay for contact allergenicity screening: measurement of interleukin-2 as an alternative to radioisotope-dependent proliferation assay.

doi:10.1016/0300-483x(95)91101-t

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Article

A modification of the local lymph node assay for contact allergenicity screening: measurement of interleukin-2 as an alternative to radioisotope-dependent proliferation assay.

Toxicology - 12 Apr 1995

Hatao M, Hariya T, Katsumura Y, Kato S

Abstract excerpt

The local lymph node assay is an effective prediction method for contact allergenicity, but employs radioisotopes. We investigated whether measurement of interleukin-2 (IL-2) production by lymph node cells could be used instead to predict contact allergenicity of chemicals. Test chemicals were ap...

Topics

Allergens
Animals
Biomarkers
Cell Division
Dermatitis, Allergic Contact
Female
Flow Cytometry
Interleukin-2
Lymph Nodes
Mice
Mice, Inbred BALB C
Phenotype
Thymidine
Tritium

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