Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BRCA2 germline mutations in male breast cancer cases and breast cancer families.

Nature genetics - 1 May 1996

Couch F J, Farid L M, DeShano M L, Tavtigian S V, Calzone K, Campeau L, Peng Y, Bogden B, Chen Q, Neuhausen S, Shattuck-Eidens D, Godwin A K, Daly M, Radford D M, Sedlacek S, Rommens J, Simard J, Garber J, Merajver S, Weber B L

Abstract excerpt

The breast cancer susceptibility gene, BRCA2 on chromosome 13q12-13, was recently isolated. Mutations in BRCA2 are thought to account for as much as 35% of all inherited breast cancer as wall as a proportion of inherited ovarian cancer. Many BRCA2-linked families also contain cases of male breast cancer. We have analysed germline DNA from 50 males with breast cancer (unselected for family history) and 26...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to DNA

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

Share to DNA Primers

Share to Genetic Markers

Share to Molecular Sequence Data

Share to Mutation

Source

Identifiers

PMID: 8673091
DOI: 10.1038/ng0596-123

Genes

BRCA2
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BRCA2 germline mutations in male breast cancer cases and breast cancer families.PMID 8673091Read ↗

Somatic mutations in the BRCA2 gene and high frequency of allelic loss of BRCA2 in sporadic male breast cancer.Semantic proximity Read ↗

Genetic analyses of male breast cancer in Israel.Semantic proximity Read ↗

Identification of a new BRCA2 large genomic deletion associated with high risk male breast cancerSemantic proximity Read ↗

Identification of the breast cancer susceptibility gene BRCA2.Semantic proximity Read ↗

Double heterozygotes of BRCA1/BRCA2 and mismatch repair gene pathogenic variants: case series and clinical implications.Semantic proximity Read ↗

Prevalence and penetrance of BRCA1 and BRCA2 gene mutations in unselected Ashkenazi Jewish women with breast cancer.Semantic proximity Read ↗

A common mutation in BRCA2 that predisposes to a variety of cancers is found in both Jewish Ashkenazi and non-Jewish individuals.Semantic proximity Read ↗

BRCA2 germline mutations in male breast cancer patients in the Polish populationSemantic proximity Read ↗

Hereditary cancer screening: Case reports and review of literature on ten Ashkenazi Jewish founder mutations.Semantic proximity Read ↗

Cancer risks in Jewish male BRCA1 and BRCA2 mutation carriers.Semantic proximity Read ↗

Mutation analysis of BRCA1 and BRCA2 in Turkish cancer families: a novel mutation BRCA2 3414del4 found in male breast cancer.Semantic proximity Read ↗

CHEK2*1100delC and male breast cancer risk in IsraelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.