Article
Inner ear defects induced by null mutation of the isk gene.
Neuron - 1 Dec 1996
Vetter D E, Mann J R, Wangemann P, Liu J, McLaughlin K J, Lesage F, Marcus D C, Lazdunski M, Heinemann S F, Barhanin J
Abstract excerpt
The isk gene is expressed in many tissues. Pharmacological evidence from the inner ear suggests that isk mediates potassium secretion into the endolymph. To examine the consequences of IsK null mutation on inner ear function, and to produce a system useful for examining the role(s) IsK plays elsewhere, we have produced a mouse strain that carries a disrupted isk locus. Knockout mice exhibit classic shaker/waltzer...
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