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Article

Yeast mutants deficient in ER-associated degradation of the Z variant of alpha-1-protease inhibitor.

Genetics - 1 Dec 1996

McCracken A A, Karpichev I V, Ernaga J E, Werner E D, Dillin A G, Courchesne W E

Abstract excerpt

Saccharomyces cerevisiae mutants deficient in degradation of alpha-1-proteinase inhibitor Z (A1PiZ) have been isolated and genetically characterized. Wild-type yeast expressing A1PiZ synthesize an ER form of this protein that is rapidly degraded by an intracellular proteolytic process known as ER-associated protein degradation (ERAD). The mutant strains were identified after treatment with EMS using a colony blot...

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Identifiers

PMID: 8978025
DOI: 10.1093/genetics/144.4.1355
PMCID: PMC1207689

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