Article
A molecular and immunohistochemical study of the MDM2 protein isoforms and p53 gene product in bronchogenic carcinoma.
The Journal of pathology - 1 Oct 1996
Gorgoulis V G, Zoumpourlis V, Rassidakis G Z, Karameris A, Rassidakis A N, Spandidos D A, Kittas C
Abstract excerpt
Forty-one bronchogenic carcinomas were investigated for expression of MDM2 protein isoforms and their relationship to p53 protein levels and p53 gene alterations using molecular and immunohistochemical techniques. The findings were correlated with the pathological features of the carcinomas. MDM2 protein was overexpressed in 26 cases (63 percent). Western blot analysis with two monoclonal antibodies, 1B10 and...
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