Cancer susceptibility in ataxia-telangiectasia.

Article

Cancer susceptibility in ataxia-telangiectasia.

Leukemia - 1 Jan 1992

Peterson R D, Funkhouser J D, Tuck-Muller C M, Gatti R A

Abstract excerpt

Ataxia-telangiectasia (A-T) is a syndrome that has an extremely high incidence of cancer. Patients with the disease are homozygous for a mutant gene, the A-T gene, located at 11q23. Of these individuals, 30-40% develop cancer. Of these cancers, 80% are lymphoid. Those heterozygous for the A-T gen...

Topics

Ataxia Telangiectasia
Chromosome Mapping
Chromosomes, Human, Pair 11
Genetic Predisposition to Disease
Heterozygote
Humans
Leukemia
Mutation
Neoplasms

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