Qualitative and quantitative assessment of meningococcal antigens to evaluate the potential strain coverage of protein-based vaccines.

doi:10.1073/pnas.1013758107

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Article

Qualitative and quantitative assessment of meningococcal antigens to evaluate the potential strain coverage of protein-based vaccines.

Proceedings of the National Academy of Sciences of the United States of America - 9 Nov 2010

Donnelly John, Medini Duccio, Boccadifuoco Giuseppe, Biolchi Alessia, Ward Joel, Frasch Carl, Moxon E Richard, Stella Maria, Comanducci Maurizio, Bambini Stefania, Muzzi Alessandro, Andrews William, Chen Jie, Santos George, Santini Laura, Boucher Philip, Serruto Davide, Pizza Mariagrazia, Rappuoli Rino, Giuliani Marzia Monica

Abstract excerpt

A unique multicomponent vaccine against serogroup B meningococci incorporates the novel genome-derived proteins fHbp, NHBA, and NadA that may vary in sequence and level of expression. Measuring the effectiveness of such vaccines, using the accepted correlate of protection against invasive meningococcal disease, could require performing the serum bactericidal assay (SBA) against many diverse strains for each...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20962280
DOI: 10.1073/pnas.1013758107
PMCID: PMC2984153

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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