Article
Glucocorticoid programming of the fetus; adult phenotypes and molecular mechanisms.
Molecular and cellular endocrinology - 20 Dec 2001
Seckl J R
Abstract excerpt
It has been long recognised that the glucocorticoid administration to pregnant mammals (including humans) reduces offspring birth weight. Epidemiologically, low weight or thinness at birth is associated with an increased risk of cardiovascular and metabolic disorders in adult life. So, does fetal exposure to glucocorticoids produce such 'programming' of adult disorders? Here data are reviewed which show, in...
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