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Article

A redox-inactive thioredoxin reduces growth and enhances apoptosis in WEHI7.2 cells.

Biochemical and biophysical research communications - 21 Jul 2000

Freemerman A J, Powis G

Abstract excerpt

Cancer cell lines transfected with thioredoxin show increased anchorage-independent growth and decreased sensitivity to induction of apoptosis by a number of anticancer drugs. The present studies were undertaken to evaluate further the role of thioredoxin in cell growth and drug-induced apoptosis. A redox-inactive mutant thioredoxin was stably transfected into WEHI7.2 mouse lymphocytic leukemia cells and two...

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Identifiers

PMID: 10903908
DOI: 10.1006/bbrc.2000.3091

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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