Commingling analysis of the distribution of a phenotype conditioned on two marker genotypes: application to plasma angiotensin-converting enzyme levels.

doi:10.1002/(SICI)1098-2272(1996)13:6<615::AID-GEPI7>3.0.CO;2-Z

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Commingling analysis of the distribution of a phenotype conditioned on two marker genotypes: application to plasma angiotensin-converting enzyme levels.

Genetic epidemiology - 1 Jan 1996

Barrett J H, Foy C A, Grant P J

Abstract excerpt

Commingling analysis is a statistical method for distinguishing between one (usually normal) distribution and a mixture of two or more distributions. It is used in genetic studies, since one mechanism giving rise to a mixture of distributions is the effect of a major gene. Plasma levels of angiotensin-converting enzyme (ACE) have been shown to be related to an insertion/deletion (I/D) polymorphism in the ACE...

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Commingling analysis of the distribution of a phenotype conditioned on two marker genotypes: application to plasma angiotensin-converting enzyme levels.

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