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Article

Activation functions of transcription factor Sp1 at U2 snRNA and TATA box promoters.

Biological chemistry Hoppe-Seyler - 1 Nov 1995

Forsberg M, Ström A C, Lillhager P, Westin G

Abstract excerpt

To localize regions in the human transcription factor Sp1, which are involved in activating transcription of the U2 snRNA gene promoter and of a TATA box gene promoter, the activation potentials of GAL4/Sp1 chimeras were analyzed in mammalian cells. In vitro mutagenesis analysis of Sp1 showed that mutation of a hydrophobic amino acid residue in glutamine-rich activation domain A impairs stimulation of...

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PMID: 8962675
DOI: 10.1515/bchm3.1995.376.11.661

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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