Article
Newly-synthesized beta-tubulin demonstrates domain-specific interactions with the cytosolic chaperonin.
Biochemistry - 10 Dec 1996
Dobrzynski J K, Sternlicht M L, Farr G W, Sternlicht H
Abstract excerpt
Tubulin folding requires two chaperone systems, i.e., the 900 kDa cytosolic chaperonin referred to as the TCP-1 complex or TRiC which facilitates folding of the alpha- and beta-tubulin subunits and a ca. 180 kDa complex which facilitates further assembly into heterodimer. beta-Tubulin mutants were expressed in rabbit reticulocyte lysates, and the effect of C-terminal, N-terminal, and internal deletions on the...
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