Isolation of allele-specific, receptor-binding-defective low density lipoproteins from familial defective apolipoprotein B-100 subjects.

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Article

Isolation of allele-specific, receptor-binding-defective low density lipoproteins from familial defective apolipoprotein B-100 subjects.

Journal of lipid research - 1 Aug 1994

Arnold K S, Balestra M E, Krauss R M, Curtiss L K, Young S G, Innerarity T L

Abstract excerpt

Familial defective apolipoprotein B-100 (FDB) is a genetic disorder apparently caused by a single amino acid substitution (Arg3500-->Gln) that disrupts the binding of low density lipoproteins (LDL) to the LDL receptor. The plasma of FDB heterozygotes contains a mixture of normal LDL and LDL that...

Topics

Alleles
Antibodies, Monoclonal
Apolipoproteins B
Binding, Competitive
Cells, Cultured
Cholesterol
Chromatography, Affinity
Fibroblasts
Genetic Testing
Heterozygote
Humans
Lipoproteins, LDL
Receptors, Lipoprotein

Source

Open in PubMed

Identifiers

PMID: 7989871

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7989871-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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