Article
Phytohemagglutinin-L (PHA-L) lectin surface binding of N-linked beta 1-6 carbohydrate and its relationship to activated mutant ras in human pancreatic cancer cell lines.
Cancer letters - 22 Oct 1996
Schwarz R E, Wojciechowicz D C, Park P Y, Paty P B
Abstract excerpt
Alterations of the N-linked carbohydrate core structure of cell surface glycoproteins (beta 1-6 branching) can be detected by phytohemagglutinin (PHA-L) lectin binding and has been linked to tumor progression and K-ras activation in colon cancer. The purpose of this study was to determine the pre...
Topics
- Concanavalin A
- Genes, ras
- Guanosine Triphosphate
- Humans
- Membrane Glycoproteins
- Mutation
- Oncogene Protein p21(ras)
- Pancreatic Neoplasms
- Phytohemagglutinins
- Tumor Cells, Cultured