Article
Beta 1-6 branching of N-linked carbohydrate is associated with K-ras mutation in human colon carcinoma cell lines.
Biochemical and biophysical research communications - 26 Jul 1995
Wojciechowicz D C, Park P Y, Paty P B
Abstract excerpt
Here the K-ras genotypes of nine colon carcinoma cell lines are compared to the protein glycosylation patterns found in these cells. By a variety of methodologies utilizing lectins to probe carbohydrate structure, we find evidence that five out of six cell lines having K-ras mutations have elevat...
Topics
- Carbohydrate Conformation
- Carbohydrate Sequence
- Carbohydrates
- Cell Membrane
- Colonic Neoplasms
- Genes, ras
- Genotype
- Glycoproteins
- Glycosylation
- Guanosine Triphosphate
- Humans
- Lectins
- Molecular Sequence Data
- Mutation
- Neoplasm Proteins
- Phenotype
- Tumor Cells, Cultured