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Article

Buried polar residues and structural specificity in the GCN4 leucine zipper.

Nature structural biology - 1 Dec 1996

Gonzalez L, Woolfson D N, Alber T

Abstract excerpt

A conserved asparagine (Asn 16) buried in the interface of the GCN4 leucine zipper selectively favours the parallel, dimeric, coiled-coil structure. To test if other polar residues confer oligomerization specificity, the structural effects of Gln and Lys substitutions for Asn 16 were characterized. Like the wild-type peptide, the Asn 16Lys mutant formed exclusively dimers. In contrast, Gln 16, despite its...

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PMID: 8946854
DOI: 10.1038/nsb1296-1011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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