Buried polar residues and structural specificity in the GCN4 leucine zipper.

doi:10.1038/nsb1296-1011

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Article

Buried polar residues and structural specificity in the GCN4 leucine zipper.

Nature structural biology - 1 Dec 1996

Gonzalez L, Woolfson D N, Alber T

Abstract excerpt

A conserved asparagine (Asn 16) buried in the interface of the GCN4 leucine zipper selectively favours the parallel, dimeric, coiled-coil structure. To test if other polar residues confer oligomerization specificity, the structural effects of Gln and Lys substitutions for Asn 16 were characterize...

Topics

Amino Acid Sequence
DNA-Binding Proteins
Dimerization
Fungal Proteins
Leucine Zippers
Models, Molecular
Molecular Sequence Data
Mutation
Protein Conformation
Protein Kinases
Saccharomyces cerevisiae Proteins

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