Article
Extrathymic differentiation of resident T cells in the joints of mice with collagen-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 1996
Arai K, Yamamura S, Hanyu T, Takahashi H E, Umezu H, Watanabe H, Abo T
Abstract excerpt
Murine collagen-induced arthritis (CIA) is known as a T cell-mediated autoimmune disease, although autoantibodies are also suspected to be associated with the onset of the disease. To determine the origin of such T cells in the joints of mice with CIA, their phenotypic properties as well as those of T cells in other immune organs were examined in DBA/1 mice. Since a significant number of mononuclear cells (MNC)...
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