Article
Extrathymic differentiation of resident T cells in the joints of mice with collagen-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 1996
Arai K, Yamamura S, Hanyu T, Takahashi H E, Umezu H, Watanabe H, Abo T
Abstract excerpt
Murine collagen-induced arthritis (CIA) is known as a T cell-mediated autoimmune disease, although autoantibodies are also suspected to be associated with the onset of the disease. To determine the origin of such T cells in the joints of mice with CIA, their phenotypic properties as well as those...
Topics
- Animals
- Arthritis
- Autoimmune Diseases
- Base Sequence
- Bone Marrow
- CD8-Positive T-Lymphocytes
- Cell Adhesion Molecules
- Cell Differentiation
- Collagen
- DNA Primers
- DNA-Binding Proteins
- Disease Models, Animal
- Gene Expression
- Homeodomain Proteins
- Joints
- Male
- Mice
- Mice, Inbred DBA