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Article

Micromolar intracellular hydrogen peroxide disrupts metabolism by damaging iron-sulfur enzymes.

The Journal of biological chemistry - 12 Jan 2007

Jang Soojin, Imlay James A

Abstract excerpt

An Escherichia coli strain that cannot scavenge hydrogen peroxide has been used to identify the cell processes that are most sensitive to this oxidant. Low micromolar concentrations of H2O2 completely blocked the biosynthesis of leucine. The defect was tracked to the inactivation of isopropylmalate isomerase. This enzyme belongs to a family of [4Fe-4S] dehydratases that are notoriously sensitive to univalent...

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Identifiers

PMID: 17102132
DOI: 10.1074/jbc.M607646200
PMCID: PMC5136138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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