Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Can immunoglobulin C(H)1 constant region domain modulate antigen binding affinity of antibodies?

15 Nov 1996

Abstract excerpt

Although the switch process is frequently associated with affinity maturation, the constant region is not assumed to play a role in Ag-Ab binding. In the present work, we demonstrate that two clonally related human monoclonal Igs sharing identical V(H) and V(L) sequences, but expressing different isotypes (IgA1kappa(PER) and IgG1kappa(PER)), bind tubulin with significantly different affinities. This difference...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glycosylation and Glycoproteins Research
Share to Monoclonal and Polyclonal Antibodies Research
Share to Protein purification and stability

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8941639
DOI: 10.1172/jci119033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Can immunoglobulin C(H)1 constant region domain modulate antigen binding affinity of antibodies?PMID 8941639Read ↗

Can isotype switch modulate antigen-binding affinity and influence clonal selection?Semantic proximity Read ↗

The efficiency of antibody affinity maturation: can the rate of B-cell division be limiting?Semantic proximity Read ↗

Antibody Isotypes for Tumor ImmunotherapySemantic proximity Read ↗

The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response.Semantic proximity Read ↗

Antigen-Induced Allosteric Changes in a Human IgG1 Fc Increase Low-Affinity Fcγ Receptor Binding.Semantic proximity Read ↗

Affinity enhancement of antibodies: how low-affinity antibodies produced early in immune responses are followed by high-affinity antibodies later and in memory B-cell responses.Semantic proximity Read ↗

Allosteric Effects between the Antibody Constant and Variable Regions: A Study of IgA Fc Mutations on Antigen BindingSemantic proximity Read ↗

Affinity‐based selection and the germinal center responseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.