Article
Increased susceptibility of islets from diabetes-prone Psammomys obesus to the deleterious effects of chronic glucose exposure.
Endocrinology - 1 Dec 1996
Gross D J, Leibowitz G, Cerasi E, Kaiser N
Abstract excerpt
Patients with noninsulin-dependent diabetes (NIDDM) show an increase in the relative plasma levels of proinsulin and proinsulin conversion intermediates, which is corrected by strict glycemic control. This observation suggests that hyperglycemia per se may be responsible for generating the aberra...
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