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Article

Effect of rosiglitazone on the differential expression of diabetes-associated proteins in pancreatic islets of C57Bl/6 lep/lep mice.

Molecular & cellular proteomics : MCP - 1 Jul 2002

Sanchez Jean-Charles, Converset Véronique, Nolan Anna, Schmid Gerhard, Wang Steven, Heller Manfred, Sennitt Matthew V, Hochstrasser Denis F, Cawthorne Michael A

Abstract excerpt

The insulin sensitizer drug, rosiglitazone, has been shown to have a protective effect on pancreatic islet cell structure and function in animal models of type 2 diabetes. The identification of new molecular targets associated both with islet cell dysfunction and protection is a crucial research goal. In the present study, a proteomics approach has been used to identify such targets. Obese C57Bl/6J lep/lep mice...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12239279
DOI: 10.1074/mcp.m200033-mcp200

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