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Article

10Sa RNA complements the temperature-sensitive phenotype caused by a mutation in the phosphoribosyl pyrophosphate synthetase (prs) gene in Escherichia coli.

Genes & genetic systems - 1 Feb 1996

Ando H, Kitabatake M, Inokuchi H

Abstract excerpt

From Escherichia coli cells with a deletion in the ssrA gene that encodes 10Sa RNA after treatment with a mutagen, we isolated two temperature-sensitive mutants, which we designated TS15 and TS101. The temperature-sensitive (ts) phenotype of the mutants could be overcome by introduction of the wild-type ssrA gene but not by the mutants of ssrA. By a complementation test using Kohara's mini-set of clones and by...

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Identifiers

PMID: 8925474
DOI: 10.1266/ggs.71.47

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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10Sa RNA complements the temperature-sensitive phenotype caused by a mutation in the phosphoribosyl pyrophosphate synthetase (prs) gene in Escherichia coli.PMID 8925474Read ↗

Temperature-sensitive mutations in various genes of Escherichia coli K12 can be suppressed by the ssrA gene for 10Sa RNA (tmRNA).Semantic proximity Read ↗

10Sa RNA, a small stable RNA of Escherichia coli, is functional.Semantic proximity Read ↗

The defective phosphoribosyl diphosphate synthase in a temperature-sensitive prs-2 mutant of Escherichia coli is compensated by increased enzyme synthesis.Semantic proximity Read ↗

A tRNA-like structure is present in 10Sa RNA, a small stable RNA from Escherichia coli.Semantic proximity Read ↗

Phenotypic characterization and complementation analysis of Bacillus subtilis 6S RNA single and double deletion mutants.Semantic proximity Read ↗

The SsrA-SmpB ribosome rescue system is important for growth of Bacillus subtilis at low and high temperatures.Semantic proximity Read ↗

Cooperation of the prs and dnaA gene products for initiation of chromosome replication in Escherichia coli.Semantic proximity Read ↗

Characterization of a temperature-sensitive Escherichia coli mutant and revertants with altered seryl-tRNA synthetase activity.Semantic proximity Read ↗

Mutations in STS1 suppress the defect in 3' mRNA processing caused by the rna15-2 mutation in Saccharomyces cerevisiae.Semantic proximity Read ↗

PRS5, the fifth member of the phosphoribosyl pyrophosphate synthetase gene family in Saccharomyces cerevisiae, is essential for cell viability in the absence of either PRS1 or PRS3.Semantic proximity Read ↗

Suppression by enhanced RpoE activity of the temperature-sensitive phenotype of a degP ssrA double mutant in Escherichia coli.Semantic proximity Read ↗

prsB is an allele of the Salmonella typhimurium prsA gene: characterization of a mutant phosphoribosylpyrophosphate synthetase.Semantic proximity Read ↗

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