Article
Expression of myosin heavy chain transcripts in normal and cardiac mutant Mexican axolotls.
Biochemistry and molecular biology international - 1 Feb 1996
Ward S M, Spinner B J, Dube A, Gaur A, Erginel-Unaltuna N, Lemanski L F, Dube D K
Abstract excerpt
In this study, we have cloned a 1.0 kb myosin heavy chain (MHC) cDNA by screening an axolotl heart cDNA library with the monoclonal antibody MF20 against a light meromyosin (LMM) region of MHC. The nucleotide sequence analysis shows 85-86% homology at the amino acid and 78-81% homology at the nucleic acid level with MHC from other vertebrates. Phylogenetic analyses suggest that axolotl beta-MHC forms a cluster...
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