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Article

The effects of clathrin inactivation on localization of Kex2 protease are independent of the TGN localization signal in the cytosolic tail of Kex2p.

Molecular biology of the cell - 1 Nov 1996

Redding K, Seeger M, Payne G S, Fuller R S

Abstract excerpt

Localization of Kex2 protease (Kex2p) to the yeast trans-Golgi network (TGN) requires a TGN localization signal (TLS) in the Kex2p C-terminal cytosolic tail. Mutation of the TLS accelerates transport of Kex2p to the vacuole by an intracellular (SEC1-independent) pathway. In contrast, inactivation of the clathrin heavy-chain gene CHC1 results in transport of Kex2p and other Golgi membrane proteins to the cell...

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Identifiers

PMID: 8930891
DOI: 10.1091/mbc.7.11.1667
PMCID: PMC276017

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