Article
Clathrin functions in the absence of the terminal domain binding site for adaptor-associated clathrin-box motifs.
Molecular biology of the cell - 1 Jul 2009
Collette John R, Chi Richard J, Boettner Douglas R, Fernandez-Golbano Isabel M, Plemel Rachael, Merz Alex J, Geli Maria Isabel, Traub Linton M, Lemmon Sandra K
Abstract excerpt
Clathrin is involved in vesicle formation in the trans-Golgi network (TGN)/endosomal system and during endocytosis. Clathrin recruitment to membranes is mediated by the clathrin heavy chain (HC) N-terminal domain (TD), which forms a seven-bladed beta-propeller. TD binds membrane-associated adaptors, which have short peptide motifs, either the clathrin-box (CBM) and/or the W-box; however, the importance of the TD...
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