Article
Allele-specific suppression of a defective trans-Golgi network (TGN) localization signal in Kex2p identifies three genes involved in localization of TGN transmembrane proteins.
Molecular and cellular biology - 1 Nov 1996
Redding K, Brickner J H, Marschall L G, Nichols J W, Fuller R S
Abstract excerpt
Kex2 protease (Kex2p) and Ste13 dipeptidyl aminopeptidase (Ste13p) are required in Saccharomyces cerevisiae for maturation of the alpha-mating factor in a late Golgi compartment, most likely the yeast trans-Golgi network (TGN). Previous studies identified a TGN localization signal (TLS) in the C-terminal cytosolic tail of Kex2p consisting of Tyr-713 and contextual sequences. Further analysis of the Kex2p TLS...
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- Alleles
- Amino Acid Sequence
- Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
- Fluorescent Antibody Technique, Indirect
- Galactose