Influence of genetic variability in the nondeletion LDL-receptor allele on phenotypic variation in French-Canadian familial hypercholesterolemia heterozygotes sharing a 'null' LDL-receptor gene defect.

doi:10.1016/0021-9150(95)05627-0

Back to search

Article

Influence of genetic variability in the nondeletion LDL-receptor allele on phenotypic variation in French-Canadian familial hypercholesterolemia heterozygotes sharing a 'null' LDL-receptor gene defect.

Atherosclerosis - 5 Jan 1996

Bétard C, Kessling A M, Roy M, Davignon J

Abstract excerpt

We investigated the associations between low density lipoprotein (LDL)-receptor gene haplotypes and lipid and lipoprotein levels in French-Canadian individuals with familial hypercholesterolemia (FH). The 112 unrelated patients studied shared the same > 10 Kb deletion in the 5' region of the LDL-...

Topics

Alleles
Canada
Female
Gene Deletion
Genetic Variation
Haplotypes
Heterozygote
Humans
Hyperlipoproteinemia Type II
Male
Receptors, LDL

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.