Article
Determinants of lipid level variability in French-Canadian children with familial hypercholesterolemia.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2001
Lambert M, Assouline L, Feoli-Fonseca J C, Brun N, Delvin E E, Lévy E
Abstract excerpt
The wide variability in the biochemical expression of familial hypercholesterolemia (FH) is only partly explained by mutational heterogeneity in the low density lipoprotein receptor (LDLR) gene. In the current study, we measured this biochemical variability in a group of children heterozygous for the >15-kb LDLR gene deletion (n=67) and examined the contribution of apolipoprotein (apo) E and B allelic variations...
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