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Linkage of Asthma and Total Serum IgE Concentration to Markers on Chromosome 12q: Evidence from Afro-Caribbean and Caucasian Populations

1 Oct 1996

Abstract excerpt

To identify genes potentially relevant in atopic asthma, we analyzed markers in chromosome 12q15-q24.1 for linkage to asthma and total serum IgE concentration. Sib-pair analyses of 10 markers in 345 full- and 219 half-sib pairs from 29 multiplex Afro-Caribbean families provided evidence for linkage to this region for both asthma and total serum IgE. Certain alleles at these loci showed significant evidence of...

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Identifiers

PMID: 8921368
DOI: 10.1006/geno.1996.0518

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Related research

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Research trail→

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Linkage of Asthma and Total Serum IgE Concentration to Markers on Chromosome 12q: Evidence from Afro-Caribbean and Caucasian PopulationsPMID 8921368Read ↗

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Significant linkage to chromosome 12q24.32-q24.33 and identification of SFRS8 as a possible asthma susceptibility gene.Semantic proximity Read ↗

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Linkage of asthma to markers on chromosome 12 in a sample of 240 families using quantitative phenotype scores.Semantic proximity Read ↗

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