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Article

[RB gene expression in gastrointestinal tract].

Nihon rinsho. Japanese journal of clinical medicine - 1 Apr 1996

Monden T, Yamamoto H, Ikeda K, Izawa H, Tsujie M, Ohnishi T, Miyoshi Y, Sekimoto M, Tomita N, Monden M

Abstract excerpt

pRB, the retinoblastoma tumor suppressor gene product, regulates the cell cycle at G1/S transition negatively. Many cell cycle regulators modulate pRB function through its phosphorylation status. G1 cyclins (cyclin D, E)/cyclin-dependent kinases (cdk2, 4) inactivates pRB through its phosphorylation, while p21 (WAF1) and p16 inhibit cdks. In several kinds of cancer, Rb gene alteration or functional inactivation of...

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PMID: 8920658

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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