Article
Activation of two mutant androgen receptors from human prostatic carcinoma by adrenal androgens and metabolic derivatives of testosterone.
Cancer detection and prevention - 1 Jan 1996
Culig Z, Stober J, Gast A, Peterziel H, Hobisch A, Radmayr C, Hittmair A, Bartsch G, Cato A C, Klocker H
Abstract excerpt
The androgen receptor (AR) plays a central regulatory role in prostatic carcinoma and is a target of androgen ablation therapy. Recent detection of mutant receptors in tumor specimens suggest a contribution of AR alterations to progression towards androgen independence. In a specimen derived from...
Topics
- Androgens
- Androstenedione
- Androsterone
- Animals
- Base Sequence
- Blood Proteins
- Complement C4
- DNA, Neoplasm
- Haplorhini
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- Prostate-Specific Antigen