Mutant androgen receptors in prostatic tumors distinguish between amino-acid-sequence requirements for transactivation and ligand binding.

doi:10.1002/ijc.2910630415

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Article

Mutant androgen receptors in prostatic tumors distinguish between amino-acid-sequence requirements for transactivation and ligand binding.

International journal of cancer - 15 Nov 1995

Peterziel H, Culig Z, Stober J, Hobisch A, Radmayr C, Bartsch G, Klocker H, Cato A C

Abstract excerpt

Mutant androgen receptors are thought to contribute to hormone resistance in prostate carcinoma. The part they play in this process, however, is ill-defined. Here we report on transactivation by 2 mutant androgen receptors from prostatic tumors with single amino-acid exchanges in their hormone-binding domains. These exchanges enhance the transactivation property of the receptors, particularly to androsterone and...

Topics

Amino Acid Sequence
Androgen Antagonists
Animals
Base Sequence
Binding Sites
Flutamide
Haplorhini
Ligands
Male
Methionine
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Prostatic Neoplasms

Protein Binding

Protein Conformation

Receptors, Androgen

Structure-Activity Relationship

Transcriptional Activation

Source

Open in PubMed

Identifiers

PMID: 7591265
DOI: 10.1002/ijc.2910630415

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7591265-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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