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Article

Mutant androgen receptors in prostatic tumors distinguish between amino-acid-sequence requirements for transactivation and ligand binding.

International journal of cancer - 15 Nov 1995

Peterziel H, Culig Z, Stober J, Hobisch A, Radmayr C, Bartsch G, Klocker H, Cato A C

Abstract excerpt

Mutant androgen receptors are thought to contribute to hormone resistance in prostate carcinoma. The part they play in this process, however, is ill-defined. Here we report on transactivation by 2 mutant androgen receptors from prostatic tumors with single amino-acid exchanges in their hormone-binding domains. These exchanges enhance the transactivation property of the receptors, particularly to androsterone and...

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Source

Identifiers

PMID: 7591265
DOI: 10.1002/ijc.2910630415

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutant androgen receptors in prostatic tumors distinguish between amino-acid-sequence requirements for transactivation and ligand binding.PMID 7591265Read ↗

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Mutations at the boundary of the hinge and ligand binding domain of the androgen receptor confer increased transactivation function.Semantic proximity Read ↗

A novel steroidal antiandrogen targeting wild type and mutant androgen receptors.Semantic proximity Read ↗

Disrupted Amino- and Carboxyl-Terminal Interactions of the Androgen Receptor Are Linked to Androgen InsensitivitySemantic proximity Read ↗

Mechanisms of androgen receptor activation in advanced prostate cancer: differential co-activator recruitment and gene expression.Semantic proximity Read ↗

A single amino acid exchange abolishes dimerization of the androgen receptor and causes Reifenstein syndrome.Semantic proximity Read ↗

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Ligand responsiveness in human prostate cancer: structural analysis of mutant androgen receptors from LNCaP and CWR22 tumors.Semantic proximity Read ↗

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