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Article

Circumvention of tamoxifen resistance by the pure anti‐estrogen ICI 182, 780

11 Nov 1993

Abstract excerpt

Both primary and acquired resistance to the growth-inhibitory effects of anti-estrogens (e.g., tamoxifen) limits the clinical usefulness of these drugs in the treatment of breast cancer. The new, steroidal anti-estrogen ICI 182,780 was tested for its ability to inhibit the proliferation of a tamoxifen-resistant variant of the parental MCF-7 human breast-cancer cell line. Two cell lines cloned from the MCF-7 line...

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Identifiers

PMID: 8244585
DOI: 10.1002/ijc.2910550529

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Circumvention of tamoxifen resistance by the pure anti‐estrogen ICI 182, 780PMID 8244585Read ↗

Human breast cancer cell lines resistant to pure anti‐estrogens are sensitive to tamoxifen treatmentSemantic proximity Read ↗

MCF7/LCC9: an antiestrogen-resistant MCF-7 variant in which acquired resistance to the steroidal antiestrogen ICI 182,780 confers an early cross-resistance to the nonsteroidal antiestrogen tamoxifen.Semantic proximity Read ↗

Modulatory effect of tamoxifen and ICI 182,780 on adriamycin resistance in MCF-7 human breast-cancer cells.Semantic proximity Read ↗

Chemosensitizing effect of tamoxifen and ICI 182,780 on parental and adriamycin-resistant MCF-7 human breast cancer cells.Semantic proximity Read ↗

Altered expression of the IGF-1 receptor in a tamoxifen-resistant human breast cancer cell lineSemantic proximity Read ↗

[Mechanism of acquired antiestrogen resistance and its management in breast cancer].Semantic proximity Read ↗

Molecular mechanisms of endocrine resistance and their implication in the therapy of breast cancer.Semantic proximity Read ↗

Response-specific antiestrogen resistance in a newly characterized MCF-7 human breast cancer cell line resulting from long-term exposure to trans-hydroxytamoxifenSemantic proximity Read ↗

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